High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis.
Journal of translational medicine
Wang X, Li S, Liu C, Zhao J, Ren G, Zhang F, Liu X, Cao S, Xu Y, Xia Z, Xia Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2024
Single-Cell Analysis
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Key Finding
The findings indicate that PLA2G2A is primarily expressed in vascular fibroblasts and shows significant cell interactions with macrophages in the early-stage, especially in complement and inflammation-related pathways. The authors also found that serum sPLA2 levels have stronger diagnostic value in patients with mild carotid artery stenosis.
Countstar Connection
Countstar Rigel S2 generated cell-count and viability measurements for the study's cell samples before single-cell analysis for the reported research.
