Hematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery.
Nature communications
Li J, Wu H, Yu Z, Wang Q, Zeng X, Qian W, Lu S, Jiang L, Li J, Zhu M, Han Y, Gao J, Qian P.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2024
Cancer Research
Stem Cell Research
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Key Finding
Further experiments validate that the vesicles carrying chemotherapy drug cytarabine (Ara-C@HSPC-Lipo) markedly inhibit proliferation, induce apoptosis and differentiation of leukemia cells, and decrease number of leukemia stem cells. Mechanically, RNA-seq reveals that Ara-C@HSPC-Lipo treatment induces apoptosis and differentiation and inhibits the oncogenic pathways.
Countstar Connection
Cell number and viability were quantified in the study's cell samples with Countstar (model not specified) during quality assessment for the reported research.
