Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway.
BMC medicine
Liu D, Liu Y, Zhu W, Lu Y, Zhu J, Ma X, Xing Y, Yuan M, Ning B, Wang Y, Jia Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2023
Microbiology
No items found.
Key Finding
GNB4 expression was significantly upregulated in GC and correlated with aggressive clinical characteristics and poor prognosis. The findings demonstrate that H. pylori infection activates the NF-κB-TET1-GNB4 demethylation-YAP1 axis, which may be a potential therapeutic target for GC.
Countstar Connection
Countstar (model not specified) was used to quantify cell numbers in the study's cell samples during the study's growth assessment.
