Granulocyte colony-stimulating factor induced T-cell hyporesponsiveness via modulation of CD177 + S100A hi neutrophils in unexplained recurrent pregnancy loss.
Clinical and translational medicine
Li PF, Zhang X, Zheng PS.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Immunology
Single-Cell Analysis
No items found.
Key Finding
G-CSF played a crucial regulatory role in improving pregnancy outcomes by selectively expanding CD177⁺S100A hi neutrophils with polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) properties, providing a solid theoretical foundation for the treatment of patients with URPL using G-CSF.
Countstar Connection
The study's cell samples underwent cell-count and viability assessment with Countstar (model not specified) before single-cell analysis for the immune-cell research.
