SCIENTIFIC EVIDENCE

GPNMB + Gal-3 + hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis.

The EMBO journal
Meng Y, Zhao Q, Sang Y, Liao J, Ye F, Qu S, Nie P, An L, Zhang W, Jiao S, Huang A, Zhou Z, Wei L.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2023
Immunology
Single-Cell Analysis
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Key Finding
Enrichment of the GPNMB + Gal-3 + MT Immu subset was found to be associated with poor prognosis and a higher rate of recurrence in patients. Collectively, the authors unraveled the single-cell HCC progression atlas and uncovered GPNMB + Gal-3 + parenchymal cells as a major subset contributing to the immunosuppressive microenvironment thus malignance in HCC.
Countstar Connection
Countstar (model not specified) measured cell viability in the study's cell samples before single-cell analysis in the 2023 The EMBO journal study.
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