Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesity.
PLoS biology
Li Y, Tao M, Ibáñez CF, Xie M.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Single-Cell Analysis
No items found.
Key Finding
ASPC-specific Gpc3 deletion in mice amplified high-fat diet-induced weight and fat mass gain, with a selective enhancement of expansion in inguinal white adipose tissue (WAT) without affecting epididymal WAT. These findings establish Gpc3 as a regulator for regional adipose plasticity, offering a molecular target for reprogramming pathological fat distribution in obesity and related metabolic disorders.
Countstar Connection
The researchers assessed nuclei numbers in isolated nuclei with Countstar Rigel S5 during preparation for single-cell or single-nucleus analysis.
