SCIENTIFIC EVIDENCE

Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2.

iScience
Jin X, Li L, Peng Q, Gan C, Gao L, He S, Tan S, Pu W, Liu Y, Gong Y, Yao Y, Wang G, Liu X, Gong M, Lei P, Zhang H, Qi S, Xu H, Hu H, Dong B, Peng Y, Su D, Dai L.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Bioprocessing
No items found.
Key Finding
Glycyrrhetinic acid (GA) is a natural product of licorice with mitochondria targeting properties and shows broad anticancer activities, but its targets and underlying mechanisms remain elusive. Modifications at GA carboxylic group with diamines significantly improved its anticancer potency, demonstrating GA as a decent structural template for SHMT2 inhibitor development.
Countstar Connection
Countstar (model not specified) supported measurement of cell numbers in the study's cell samples during the study's growth assessment.
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