SCIENTIFIC EVIDENCE

Global transcriptomic characterization of T cells in individuals with chronic HIV-1 infection.

Cell discovery
Wang XM, Zhang JY, Xing X, Huang HH, Xia P, Dai XP, Hu W, Zhang C, Song JW, Fan X, Wu FY, Liu FH, Ke Y, Zhao Y, Jiang TJ, Wang LF, Jiao YM, Xu RN, Jin L, Shi M, Bai F, Wang FS.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Immunology
Single-Cell Analysis
No items found.
Key Finding
Through analyzing the transcriptional profiles of CD4 + and CD8 + T cells, coupled with assembled T cell receptor sequences, the authors observed the significant loss of naive T cells, prolonged inflammation, and increased response to interferon-α in TP individuals, which could be partially restored by ART.
Countstar Connection
Using Countstar (model not specified), the study measured cell measurements in cell suspensions during preparation for single-cell or single-nucleus analysis.
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