A geometry-informed continuous 3D IEQ framework enables more accurate dose estimation in stem cell-derived islet transplantation

A geometry-informed continuous three-dimensional islet-equivalent framework was developed to improve dose estimation for stem cell-derived islet transplantation. By representing aggregate geometry more accurately than conventional two-dimensional assumptions, the method improved estimates of transplanted cell mass and supports more consistent interpretation of functional transplantation studies.

Dissociated stem cell-derived islet cells were quantified with the Countstar Mira BF, enabling insulin secretion measurements to be normalized to cell number.