Functional human salivary gland organoids for tissue regeneration in chemically defined culture systems.
Cell reports. Medicine
Zhang X, Chai Y, Qiu J, Shan X, Xie S, Sui Y, Cai Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
3D Culture
Organoid Culture
Single-Cell Analysis
No items found.
Key Finding
In the orthotopic transplantation model using non-obese diabetic mice with Sjögren syndrome, the organoids significantly improve salivary secretion. This study establishes a robust, functionally mature, and clinically translatable human salivary gland organoid system as a platform for tissue regeneration therapies targeting salivary hypofunction disorders such as Sjögren syndrome.
Countstar Connection
The study used Countstar (model not specified) for cell-viability assessment in the study's cell samples during preparation for single-cell or single-nucleus analysis.
