SCIENTIFIC EVIDENCE

Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication

International Journal of Biological Sciences

Xiangguang Shi, Xueyi Xia, Yang Xiao, Huizhen Shu, Zhuoya Xu, Mengguo Liu, Chenyi Shi, Ying Zhang, Yining Wei, Yiyi Gong, Wei Wang, Yahui Chen, Jianlan Liu, Jia Huang, Mengkun Shi, Jiucun Wang, Wenyu Wu

Publication Overview

Key findings, Countstar context, and access to the original paper.

2025

Cell Counting & Viability

Mira FL

Key Finding

This study identifies ferroptosis-resistant dermal adipocytes as drivers of keloid disease. It links GPX4-dependent adipocyte–mesenchymal transition and iron–cystine metabolic communication to pathological fibrosis, and reports that targeting this axis reduced keloid-related activity in experimental models.

Countstar Connection

Measured fibroblast and melanocyte growth after cell detachment in the proliferation assay.

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