SCIENTIFIC EVIDENCE

FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single-Cell RNA-Seq Samples.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Wang X, Ma Y, Li F, Cui W, Pan T, Wang S, Ma S, Shan Q, Liu C, Wang Y, Zhang Y, Zhou Y, Li W, Wang P, Zhou Q, Feng G.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
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Key Finding
In each organ, the authors identify candidate XCI-escaping genes, and within each cell type, the authors observe gene expression differences associated with XCI origin, potentially contributing to phenotypic variability. Furthermore, FemXpress demonstrated strong performance in phasing XCI in scRNA-Seq datasets from embryos and colon tumors.
Countstar Connection
The study measured cell measurements in cell suspensions using Countstar (model not specified) before single-cell analysis for the study's single-cell analysis.
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