SCIENTIFIC EVIDENCE

Fedratinib Attenuates Bleomycin-Induced Pulmonary Fibrosis via the JAK2/STAT3 and TGF-β1 Signaling Pathway.

Molecules (Basel, Switzerland)

Ruan H, Luan J, Gao S, Li S, Jiang Q, Liu R, Liang Q, Zhang R, Zhang F, Li X, Zhou H, Yang C.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2021

Immunology

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Key Finding

In vitro studies have shown that Fed attenuates TGF-β1- and IL-6-induced myofibroblast activation and inflammatory response by regulating the JAK2/STAT3 signaling pathway. In vivo studies have shown that Fed can reduce bleomycin-induced inflammation and collagen deposition and improve lung function.

Countstar Connection

Cell-count assessment in the study's cell samples used Countstar (model not specified) during quality assessment for the reported research.

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