SCIENTIFIC EVIDENCE

Fatty acid oxidation drives acetyl-CoA-dependent H3K9ac reprogramming to promote adaptive resistance to BRAF V600E inhibition in thyroid cancer.

Cell death & disease

Wang X, Zhang J, Yuan J, Wen L, Ying T, Xu Z, Zhou Z, Chen S, Zhou Q, Sheng J, Luo C, Teng L, Wang W.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2026

3D Culture

Cancer Research

Organoid Culture

Castor S

Key Finding

In addition, higher expression of RUNX1 correlates with poorer prognosis in thyroid cancer. The work reveals a metabolic-epigenetic axis underlying adaptive response to BRAFi and identifies RUNX1 as a novel oncogene in thyroid cancer.

Countstar Connection

Cell viability was assessed in the study samples with Countstar Castor S1 within the organoid or 3D-culture workflow.

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