EPI-SauriCas9-based mouse ovarian cancer models recapitulating pten deletion in patients.
Communications biology
Chen W, He P, Ding L, Lou W, Wang Y, Shi W, Fan Z, Sheng Y, Luo J, Tan Z, Wang Y, Di W, Ke X, Yu B.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
Single-Cell Analysis
No items found.
Key Finding
High-throughput drug screening identifies FK228 and thioguanine as promising therapeutic candidates, both of which show in vivo efficacy and are validated in PTEN-deleted organoids. Together, these establish MEPP as a platform for studying PTEN-deleted ovarian cancer and provide a strategy for generating clinically relevant tumor models through targeted gene editing.
Countstar Connection
Countstar (model not specified) measured cell viability in the study's cell samples before single-cell analysis for the cancer-model experiments.
