Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer.
Oncology research
Yang R, Yuan D, Liang C, Zhu S, Huang J, Zhang Y, He W, Li Q, Zhang H.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
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Key Finding
EDN1 expression is markedly upregulated in oxaliplatin-resistant CRC cells and is significantly associated with poor patient survival outcomes. The study demonstrates that EDN1 governs oxaliplatin resistance through the β-arr1/YAP axis and provides preclinical evidence for targeting EDN1 to overcome chemoresistance in CRC.
Countstar Connection
Countstar Rigel S5 served as the instrument for cell-count assessment in the study's cell samples during quality assessment in the 2025 Oncology research study.
