SCIENTIFIC EVIDENCE

Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy.

Nature communications
Jiang B, Bai F, Hu Y, Ren Y, Su Y, Song W, Xie K, Wang D, Pan J, Liu Y, Feng Y, Li X, Zhang H, Zhu X, Bai H, Yang Q, Ben J, Chen Q.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
No items found.
Key Finding
These demonstrate that MVP acts as an intracellular regulator promoting Parkin-mediated mitophagy. The findings suggest that MVP/NEDD4L/Parkin axis may serve as the therapeutic target for treating intimal hyperplasia and atherosclerosis.
Countstar Connection
Within the research, Countstar (model not specified) assessed cell viability in the study's cell samples before single-cell analysis in the 2025 Nature communications study.
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