Embelin Promotes Oncolytic Vaccinia Virus-Mediated Antitumor Immunity Through Disruption of IL-6/STAT3 Signaling in Lymphoma.
OncoTargets and therapy
Wang P, Wu Y, Yang C, Zhao G, Liu Y, Cheng G, Wang S.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2020
Cancer Research
Immunology
Microbiology
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Key Finding
In addition, embelin significantly increased the OVV-induced infiltration of T cells and NK cells and decreased the number of OVV-induced myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment. The findings indicate the utility of embelin as an adjuvant for oncolytic viro-immunotherapy.
Countstar Connection
The researchers relied on Countstar (model not specified) to measure cell number and viability in the study's cell samples during quality assessment for the cancer-model experiments.
