Dual formation mechanisms of acidic variants in cysteine-engineered antibodies and strategies for their reduction
Frontiers in Bioengineering and Biotechnology
Shasha Zhou, Xinyu Cao, Xuefei Yin, Jiawen Xu, Kai Gao, Zhenshou Wang
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cell Counting & Viability
No items found.
Key Finding
This bioprocessing study investigated acidic variants in cysteine-engineered antibodies and methods to reduce them. The authors distinguish dual formation mechanisms and evaluate culture and process strategies intended to limit variant formation during recombinant antibody production.
Countstar Connection
Measured CHO cell number and viability during antibody-production cultures.
