SCIENTIFIC EVIDENCE

Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma.

Oncotarget
Li C, Meng G, Su L, Chen A, Xia M, Xu C, Yu D, Jiang A, Wei J.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2015
Cancer Research
Microbiology
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Key Finding
DCA enhanced viral replication by mitigating mitochondrial antiviral signaling protein (MAVS)-mediated innate immune responses. Taken together, oncolytic MV-Edm sensitized cancer cells to DCA, and in parallel, DCA promoted viral replication, thus, improving oncolysis.
Countstar Connection
The study's cell samples underwent cell-count and viability assessment with Countstar (model not specified) during quality assessment for the microbiology research.
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