Deubiquitinase Ubp5 Is Required for the Growth and Pathogenicity of Cryptococcus gattii.
PloS one
Meng Y, Zhang C, Yi J, Zhou Z, Fa Z, Zhao J, Yang Y, Fang W, Wang Y, Liao WQ.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2016
Bioprocessing
Immunology
Microbiology
No items found.
Key Finding
Attenuated virulence of the Cg-ubp5Δ mutant was not solely due to its reduced thermotolerance at 37°C, as shown in both worm and mouse survival assays. In addition, the assessment of fungal burden in mammalian organs further indicated that Ubp5 was required for C. gattii pulmonary survival and, consequently, extrapulmonary dissemination.
Countstar Connection
For yeast samples, researchers obtained cell-count measurements with Countstar (model not specified) during growth assessment for the reported research.
