Denosumab Regulates Titanium Particles-Induced Macrophages Inflammation and Osteolysis by Targeting the ST18/PARP1 Interaction.
Orthopaedic surgery
Chen Z, Yang F, Yu Y, Chen J, Ye J, Ding Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Immunology
No items found.
Key Finding
A mouse calvarial model of TiPs-induced osteolysis was established, and the roles of Denosumab and ST18 were examined in vivo using micro-CT, H&E staining, and tartrate-resistant acid phosphatase (TRACP) staining. Further analysis revealed that ST18 interacts with PARP1.
Countstar Connection
Researchers relied on Countstar (model not specified) for cell-count and viability measurements in the study's cell samples during culture monitoring in the 2026 Orthopaedic surgery study.
