DEFA5-producing CD4 + T cells in the intestines of atopic dermatitis patients play an important role in the development of AD-associated intestinal inflammation.

Rationale Atopic dermatitis (AD) is associated with various gastrointestinal symptoms, yet the underlying mechanisms remain poorly understood. This suggests that the DEFA5-expressing CD4 + IELs could be a potential therapeutic target for managing gastrointestinal symptoms in AD patients.

Countstar (model not specified) was the instrument used to assess cell viability in single-cell suspensions during preparation for single-cell or single-nucleus analysis.