Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing.
Science advances
Xing X, Yang F, Huang Q, Guo H, Li J, Qiu M, Bai F, Wang J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2021
Cancer Research
Single-Cell Analysis
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Key Finding
The findings show that cytotoxic natural killer/T cells were dominant in the TME of SSN, and malignant cells in SSN undergo a strong metabolic reprogram and immune stress. This resource provides deeper insight into the indolent nature of SSN and will be helpful in advancing lung cancer immunotherapy.
Countstar Connection
Researchers assessed cell concentration and viability in the study's cell samples using Countstar (model not specified) before single-cell analysis for the study's single-cell analysis.
