SCIENTIFIC EVIDENCE

Deciphering signaling mechanisms and developmental dynamics in extraembryonic mesoderm specification from hESCs.

Nature communications
Niu B, Wang D, Hu Y, Wang Y, Shi G, Chen Z, Xiang L, Zhang C, Wei X, Kong R, Cai H, Ji W, Yin Y, Li T, Ai Z.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
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Key Finding
The authors reveal that ExM specification from hESCs predominantly proceeds through intermediates exhibiting a primitive streak (PS)-like gene expression pattern and delineate the regulatory roles of WNT and Nodal signaling in this process.
Countstar Connection
Within the study, Countstar (model not specified) measured cell numbers in the study's cell samples during preparation for single-cell or single-nucleus analysis.
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