Cyclin Y interacts with Chk1 to activate RRM2/STAT3 signaling and promotes radioresistance in non-small cell lung cancer.
International journal of biological sciences
Liu Z, Xue H, Wang Z, Zhao Y, Xu S, Dong X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
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Key Finding
Furthermore, knockdown of Cyclin Y in inhibited cell growth and proliferation, increases DNA damage, impairs DNA damage repair, and enhances radiosensitivity in vitro and in vivo. Mechanistically, the authors uncover that Cyclin Y interacts with Chk1 and positively regulate both the mRNA and protein levels of RRM2, resulting in increased STAT3 phosphorylation.
Countstar Connection
Within the study, Countstar (model not specified) measured cell numbers in the study's cell samples during the study's growth assessment.
