Furthermore, knockdown of Cyclin Y in inhibited cell growth and proliferation, increases DNA damage, impairs DNA damage repair, and enhances radiosensitivity in vitro and in vivo. Mechanistically, the authors uncover that Cyclin Y interacts with Chk1 and positively regulate both the mRNA and protein levels of RRM2, resulting in increased STAT3 phosphorylation.
Countstar Connection
Within the study, Countstar (model not specified) measured cell numbers in the study's cell samples during the study's growth assessment.
