CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia.
Nature communications
Liu T, Wang T, Qi L, Liu Y, Shan M, Wang F, Fang Y, Liu S, Wen L, Chen S, Wu D, Xu Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
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Key Finding
Mechanistically, CR fusion interacts with histone deacetylase 3 (HDAC3) to suppress expression of genes associated with myeloid differentiation including the myeloid transcription factor PU.1. Hence, the data reveals the molecular bases of oncogenic CR fusion and provides a potential therapeutic approach against AML with CR fusion.
Countstar Connection
The researchers assessed cell numbers in the study's cell samples with Countstar (model not specified) during sample-quality assessment.
