Constitutively active glucagon receptor drives high blood glucose in birds.
Nature
Zhang C, Xiang X, Liu J, Huang Y, Xue J, Sun Q, Leng S, Liu S, He X, Hu P, Zhan X, Qiu Q, Yang S, Brosius J, Deng C.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cell Counting & Viability
No items found.
Key Finding
Furthermore, the authors identified a point mutation proximal to the GCGR gene region in chicken that ed in reduced GCGR mRNA expression and increased body weight. Overexpressing a natural human GCGR variant (HsGCGR(H339R)) with modest constitutive activity in mice demonstrated that high expression of this variant increased blood glucose concentration and reduced body weight.
Countstar Connection
Countstar Rigel S2 was used to quantify nuclei numbers in isolated nuclei during sample-quality assessment.
