Colony‑stimulating factor CSF2 mediates the phenotypic plasticity of small‑cell lung cancer by regulating the p‑STAT3/MYC pathway.
Oncology reports
Li H, Zhong R, He C, Tang C, Cui H, Li R, Liu Y, Lan S, Cheng Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2022
Cancer Research
Immunology
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Key Finding
The STRING, Pathway Commons and Reactome databases showed a potential regulatory relationship between CSF2 and phosphorylated signal transducer and activator of transcription 3 (p‑STAT3)/MYC. p‑STAT3 and MYC expression was higher in H69A cells than in H69S cells and CSF2 silencing inhibited their expression.
Countstar Connection
Cell numbers were quantified in the study's cell samples with Countstar (model not specified) during growth assessment for the cancer-model experiments.
