SCIENTIFIC EVIDENCE

Characterization of Early Metastatic Subpopulations in Uveal Melanoma: Single-Cell Insights Into SPP1+ Cells and Their Interactions With Macrophages.

Investigative ophthalmology & visual science
Luo J, Zeng J, Wang H, Qian Q, Li H, Chen Y, Xiu J, Fang R, Yang Q, Feng Z, Li Y, Xiao J, Wei W.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
Immunology
Single-Cell Analysis
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Key Finding
In vitro experiments supported that SPP1 regulates UM cell proliferation, migration, and invasion. The study reveals early metastatic mechanisms in UM by identifying highly invasive SPP1+ melanoma cells and their interaction with macrophages, providing potential therapeutic targets for the metastatic process.
Countstar Connection
Researchers used Countstar (model not specified) to assess cell number and viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.
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