SCIENTIFIC EVIDENCE

Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling.

Cell discovery
Ai J, Guo J, Zhang H, Zhang Y, Yang H, Lin K, Song J, Fu Z, Fan M, Zhang Q, Wang H, Zhao Y, He Z, Cui A, Zhou Y, Wu J, Zhou M, Yuan G, Kang B, Zhao N, Xu Y, Zhu M, Wang Y, Zhang Z, Jiang N, Qiu C, Xu C, Zhang W.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Immunology
Single-Cell Analysis
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Key Finding
The production of antibody was positively correlated with antigen presentation by conventional dendritic cells (cDCs), which provides support for B cell maturation through activation and development of follicular helper T (Tfh) cells. The study unveils the cellular mechanisms of booster-induced memory/adaptive humoral immunity and suggests potential strategies to optimize vaccine efficacy and durability in future iterations.
Countstar Connection
Countstar (model not specified) measured cell concentration and viability in the study's cell samples before single-cell analysis for the study's single-cell analysis.
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