SCIENTIFIC EVIDENCE

CCL5 hiCD4+ T Cells Regulate Macrophage Polarization and Promote Immunotherapy Response in Bladder Cancer.

Cancer research

Luo W, Wang Y, Wang H, Ji YA, Zhang J, Ran Q, Ao Y, Xu J, Zhang J, Cheng X, Wang L, Zhang Y, Zhang J, Ai C, Qin J, Jiang J, Lan W, Liu Q.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2026

Cancer Research

Immunology

Single-Cell Analysis

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Key Finding

In this study, the authors identified a population of CCL5hiCD4+ T cells that were characterized by memory-like activation markers and strongly correlated with ICI therapeutic responses in bladder cancer. Functionally, these T cells enhanced antitumor immunity by promoting M1-like macrophage polarization through CCL5/CCR1 signaling.

Countstar Connection

Measurement of cell viability in the study's cell samples was performed with Countstar (model not specified) before single-cell analysis in the 2026 Cancer research study.

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