C5a/C5aR pathway blocking promoted CuS-mediated cancer therapy effect by inhibiting cuproptosis resistance.
Journal for immunotherapy of cancer
Yang H, Deng B, Han X, Wang L, Zhao J, Zhao Y, Sun Z, Wang S, Liu G, Wu Y, Chen J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
No items found.
Key Finding
Therefore, it is essential to further investigate the mechanisms underlying cuproptosis resistance to enhance its therapy effect. The findings indicated that activation of the C5a/C5aR pathway contributes to cuproptosis resistance by upregulating ATP7B expression via the Wnt/β-catenin pathway.
Countstar Connection
In this work, Countstar (model not specified) measured sample absorbance in the study samples during quality assessment for the cancer-model experiments.
