B7-H3 Chimeric Antigen Receptor Redirected T Cells Target Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma.
Cancers
Zi Z, Zhao H, Wang H, Ma X, Wei F.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2020
Cancer Research
Immunology
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Key Finding
B7-H3 CAR-T cells showed strong cytotoxicity and cytokine secretion against target ALCL cells (SUP-M2, SU-DHL-1, and Karpas 299) in vitro. The authors demonstrated that B7-H3 CAR-T cells could promptly eradicate ALCL in murine xenografts.
Countstar Connection
The research used Countstar (model not specified) for cell-concentration, viability, and size assessment in the study's cell samples during quality assessment for the cancer-model experiments.
