Aqueous extracts of Sanghuangporus vaninii induce S-phase arrest and apoptosis in human melanoma A375 cells.
Oncology letters
Yu T, Zhong S, Sun Y, Sun H, Chen W, Li Y, Zhu J, Lu L, Huo J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2021
Cancer Research
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Key Finding
Reverse transcription-quantitative PCR, western blotting and immunofluorescence analyses indicated that SH induced S-phase arrest by upregulating p21 expression, and p21 inhibited the expression of cyclin-cyclin-dependent kinases complexes at both the RNA and protein levels. Therefore, the suggested that SH may be a potential candidate for the treatment of human melanoma, thus providing new ideas for developing drugs that target melanoma.
Countstar Connection
A Countstar instrument supported assessment of cell numbers in cell suspensions during growth assessment in the 2021 Oncology letters study.
