APOE4-driven T cell dysregulation in Alzheimer's disease: single-cell genomics and Mendelian randomization reveal novel therapeutic targets.
Journal of neuroinflammation
Zheng D, Gu J, Nao J, Sun M, Dong X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Immunology
Single-Cell Analysis
No items found.
Key Finding
The ɛ4 allele of the apolipoprotein E gene (APOE4) has been identified as a significant risk factor for late-onset AD. The study's integrative analysis suggests that genetically determined levels of circulating BHLHE40, ANXA1, and RUNX3, may be promising biomarkers for AD and warrant further clinical investigation.
Countstar Connection
Using Countstar Rigel S2, the study assessed cell concentration and viability in the study's cell samples before single-cell analysis in the 2026 Journal of neuroinflammation study.
