SCIENTIFIC EVIDENCE

Aorta Regulatory T Cells with a Tissue-Specific Phenotype and Function Promote Tissue Repair through Tff1 in Abdominal Aortic Aneurysms.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Li J, Xia N, Li D, Wen S, Qian S, Lu Y, Gu M, Tang T, Jiao J, Lv B, Nie S, Hu D, Liao Y, Yang X, Shi G, Cheng X.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Immunology
Single-Cell Analysis
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Key Finding
Foxp3 cre/cre Tff1 flox/flox mice are used to clarify the role of Tff1 in AAA, suggesting that aortic Tregs secrete Tff1 to regulate smooth muscle cell (SMC) survival. The findings reveal a tissue-specific phenotype and function of aortic Tregs and may provide a promising and novel approach for the prevention of AAA.
Countstar Connection
Cell suspensions underwent cell assessment with Countstar (model not specified) before single-cell analysis in the 2022 Advanced science study.
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