Antifibrotic Mechanism of Cinobufagin in Bleomycin-Induced Pulmonary Fibrosis in Mice.
Frontiers in pharmacology
Li X, Bi Z, Liu S, Gao S, Cui Y, Huang K, Huang M, Mao J, Li L, Gao J, Sun T, Zhou H, Yang C.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2019
Immunology
No items found.
Key Finding
The in vivo experiments indicated that cinobufagin significantly alleviates bleomycin-induced collagen deposition and improves pulmonary function. Further study showed that cinobufagin could attenuate bleomycin-induced inflammation and inhibit fibroblast activation and the EMT process in vivo.
Countstar Connection
The study's cell samples underwent cell-count assessment with Countstar (model not specified) during quality assessment in the 2019 Frontiers in pharmacology study.
