An insulin receptor activity surge in follicle cells drives vitellogenesis by upregulating CrebA.
EMBO reports
Wang X, Liu H, Yin Z, Shao T, Li L, Ma J, He F.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Cell Counting & Viability
No items found.
Key Finding
The findings suggest a critical role of CrebA in implementing the stage-specific effect of insulin signaling to boost the secretory capacity of follicle cells. Mechanistically, CrebA is directly repressed by nuclear FoxO that is subject to insulin control, a regulatory axis that the authors show is conserved in human granulosa cells.
Countstar Connection
Countstar (model not specified) measured flow-cytometry cell measurements in cell suspensions before single-cell analysis in the 2026 EMBO reports study.
