Ammonia promotes the proliferation of bone marrow-derived mesenchymal stem cells by regulating the Akt/mTOR/S6k pathway.
Bone research
Liu Y, Zhang X, Wang W, Liu T, Ren J, Chen S, Lu T, Tie Y, Yuan X, Mo F, Yang J, Wei Y, Wei X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2022
Stem Cell Research
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Key Finding
The study demonstrated that mesenchymal stem cells can convert the toxic waste product ammonia into nutritional glutamine via GS activity. These suggest a new therapeutic strategy and potential target for the treatment of diseases involving hyperammonemia.
Countstar Connection
Measurement of cell numbers in cell suspensions was performed with Countstar (model not specified) during growth assessment in the 2022 Bone research study.
