SCIENTIFIC EVIDENCE

ALYREF condensation stabilizes m 5 C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer.

The EMBO journal

Zhao H, Wei Q, Luo Z, Liu X, Yang C, Chen N, Wang Y, Luo X, Zuo X, Luo Q, Yang Y, Zhou Y, Liu J, Zhang T, Yang D, Long Y, Mobet Y, Xu J, Wang W, Liu T, Yi P.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2026

Cancer Research

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Key Finding

Together, these findings suggest that ALYREF phase separation facilitates the malignant progression of ovarian cancer by promoting PARP10 expression and thereby enhancing PARP10-dependent proliferative pathways in a m 5 C-dependent manner.

Countstar Connection

The study's cell samples underwent cell-count assessment with Countstar (model not specified) during the study's growth assessment.

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