Alternative Polyadenylation Drives Runaway Pro-Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression.
Cell proliferation
Zhang J, Zhao Y, Deng J, Qu S, Zhou Y, Zhao Q, Zhang Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Immunology
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Key Finding
The study identify alternative polyadenylation (APA) as a critical post-transcriptional mechanism driven by pathogens to disrupt macrophage immune control. Collectively, these findings reveal APA remodelling as a key pathogenic strategy that enables pro-inflammatory macrophages to escape miRNA-mediated suppression, leading to an uncontrolled M1-like state.
Countstar Connection
Researchers relied on Countstar Rigel S2 for cell-count and viability measurements in the study's cell samples during preparation for single-cell or single-nucleus analysis.
