Age- and sex-dependent bone marrow adiposity and distinct transcriptional trajectories in endothelial subtypes.
Scientific reports
Syed UI, Hsu M, Howlett CJ, Khan ZA.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Single-Cell Analysis
No items found.
Key Finding
The findings reveal that vascular ageing is not a uniform decline but a subtype-specific mosaic of failure. The selective dysfunction and bioenergetic collapse of SECs emerge as a central driver of niche degradation, identifying this population as a key therapeutic target to combat age-related hematopoietic dysfunction.
Countstar Connection
Countstar (model not specified) was the instrument used to assess cell viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.
