Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus.
Cell death & disease
Fan H, Liu F, Dong G, Ren D, Xu Y, Dou J, Wang T, Sun L, Hou Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2014
Immunology
No items found.
Key Finding
These data indicate that co-activation of TLR7 and BCR pathways can promote B cells to hyperactivation and ultimately necroptosis. These data suggest that extrinsic factors may increase the intrinsical abnormality of B cells in SLE patients.
Countstar Connection
Countstar (model not specified) measured cell numbers in the study's cell samples during quality assessment in the 2014 Cell death & disease study.
