SCIENTIFIC EVIDENCE

Acoustic virtual 3D scaffold for direct-interacting tumor organoid-immune cell coculture systems.

Science advances
Shan H, Chen M, Zhao S, Wei X, Zheng M, Li Y, Lin Q, Jiang Z, Chen Z, Fei C, Li Z, Chen Z, Chen X.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2024
3D Culture
Cancer Research
Immunology
Organoid Culture
Key Finding
This approach can significantly enhance the influx of calcium ions, thereby accelerating intercellular interactions of cellular assemblies. The authors found that the study's coculture system ed in a high activation state of T cells, characterized by notable up-regulation of granzyme B (2.82 to 17.5%) and interferon-γ (1.36 to 16%).
Countstar Connection
The study used Countstar Mira BF for live- and dead-cell count assessment in tumor-cell samples within the organoid or 3D-culture workflow.
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