A skin organoid-based infection platform identifies an inhibitor specific for HFMD.
Nature communications
Li J, Ma J, Cao R, Zhang Q, Li M, Wang W, Wang Y, Li W, Zhu Y, Leng L.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
3D Culture
Organoid Culture
Single-Cell Analysis
No items found.
Key Finding
The authors elucidate the specific response of different cell types to EV-A71 and reveal that EV-A71 infection can degrade extracellular collagen and affect fibroblasts. Based on this finding, the authors identify an autophagy-associated protein as a drug target of EV-A71 and discover an EV-A71 replication inhibitor.
Countstar Connection
Countstar Rigel S2 measured cell concentration and viability in the study's cell samples before single-cell analysis for the organoid or 3D-culture experiments.
