A single-cell and spatial transcriptomic atlas of human tuberculous constrictive pericardium.
EBioMedicine
Xiong F, Qi Y, Wang S, Zhang L, Cheng F, Tan K, Chen J, Lei Y, Yang W, Zhao Z, Huang L, Cheng L, Luo Y, Wang Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Immunology
Single-Cell Analysis
No items found.
Key Finding
Ligand-receptor analysis and spatial co-localisation suggested macrophages may act as hubs that couple immune activation to endothelial reprogramming, fibroblast activation, and T-cell recruitment within fibrotic lesions. The study's findings show that a spatially organised immune-endothelial-fibroblast network is associated with pericardial fibrosis and nominate VEGF/TGF-β pathways and associated cell states as potential biomarkers and therapeutic targets.
Countstar Connection
The researchers assessed cell number and viability in the study's cell samples with Countstar Rigel S2 during preparation for single-cell or single-nucleus analysis.
