A pro-inflammatory neutrophil subpopulation drives intestinal ischemia-reperfusion injury via the ATF4-mediated endoplasmic reticulum stress pathway.
Scientific reports
Yang Y, Zhou Q, Liu S, Wu B, Wu J, Xu Y.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Immunology
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Key Finding
These findings demonstrate that a specific neutrophil subpopulation aggravates intestinal IRI through the intrinsic ERS/ATF4 pathway, providing a novel perspective on IRI pathophysiology and highlighting a potential therapeutic target for mitigating intestinal damage.
Countstar Connection
Countstar Rigel S2 was used to quantify cell number and viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.
