SCIENTIFIC EVIDENCE

A multi-omics integrative analysis based on CRISPR screens re-defines the pluripotency regulatory network in ESCs.

Communications biology
Ruan Y, Wang J, Yu M, Wang F, Wang J, Xu Y, Liu L, Cheng Y, Yang R, Zhang C, Yang Y, Wang J, Wu W, Huang Y, Tian Y, Chen G, Zhang J, Jian R.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2023
Cancer Research
Stem Cell Research
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Key Finding
Spatiotemporal transcriptomics reveal activated CORE/MYC/PAF module activity and repressed PRC/PCGF/TBX module activity in both mouse ESCs (mESCs) and pluripotent cells of early embryos. Moreover, this module activity pattern is found to be shared by human ESCs (hESCs) and cancers.
Countstar Connection
Measurement of cell numbers in the study's cell samples was performed with Countstar (model not specified) during growth assessment in the 2023 Communications biology study.
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