A distinct subgroup with Schwann-like differentiation presents immune resistance and poor prognosis in plantar melanoma.
Theranostics
Tian J, Zhang L, Zhuang L, Lin P, Zhang S, Yan Y, Yang Y, Zhang G, Li H, Lai B.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
Immunology
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Key Finding
This study reveals the unique evolutionary trajectory of plantar melanoma, showing its differentiation towards a Schwann-like fate regulated by HMGA2, leading to a decline in pigment function, enhanced immune tolerance and an increased propensity for lymph node metastasis.
Countstar Connection
The researchers measured cell measurements in the study's cell samples with Countstar Rigel S2 before single-cell analysis in the 2025 Theranostics study.
